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Description

A study published in the New England Journal of Medicine showed a mean weight reduction of 24.2% at 48 weeks with the highest dose (12 mg), suggesting a potent step-change in efficacy

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Adverse Effects Common adverse effects: Nausea Vomiting Diarrhea Less common adverse effects: Pancreatitis Injection site reactions Precautions: Avoid in patients with severe gastrointestinal disease Contraindicated in patients with medullary thyroid carcinoma or MEN2 syndrome for certain agents Comparative Analysis Explanation: GLP-1 analogues directly activate GLP-1 receptors, producing stronger incretin effects than DPP-4 inhibitors, which simply prevent degradation of endogenous GLP-1

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The study results also revealed a significant reduction in malondialdehyde, the livers cell damage marker

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