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Methods in enzymology

Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis

Using animal models and in vitro experiments, Thomas et al investigated the potential for off-target inhibition of DPP family member enzymatic activity by linagliptin

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It not only suppressed the aberrant activation of the ECM, TGF-, and focal adhesion pathways but also restored the expression of VEGF and BMP family genes that are crucial for tissue homeostasis