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On a chemical pathway, excessive production of ROS induces oxidation of tetrahydrobiopterin (BH4), a cofactor of endothelial NOS, which produces NO from l-arginine

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Such, P., Strakov, E

Diabetes is associated with several pathways, one of which is the activation of the polyol route, the production of oxidative stress, poly ADP-ribose polymerase, the formation of advanced glycation outputs, and the pathways of hexosamine