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Subsequent research has reinforced these concerning findings, with a Danish nationwide cohort study of 424,152 type 2 diabetes patients demonstrating that semaglutide doubled the five-year NAION risk compared to other treatments

Because of the slowed gastric emptying, many patients have gastrointestinal side effects that can often limit a patients ability to take these drugsespecially at the high doses recommended for weight loss

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Of the 8,803 patients in the semaglutide group, 569 (6.5%) experienced a primary cardiovascular end-point event, such as a heart attack, compared with 701 (8%) of the 8,801 patients in the placebo group