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The mechanisms of lysosomal degradation and autophagy are crucial to remove potentially toxic and protective fatty acids against ER stress-induced cell death [129,130,131]

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Patients without Neurofibromatosis type 1 (NF1) tend to have better outcomes than those with NF1-associated MPNST, as NF1-related tumors are more likely to be multifocal, high-grade, and resistant to therapy (Evans et al., 2021)

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