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Results IF increases the abundance of crown-like structures in AT To study AT plasticity in response to fasting cues, we induced obesity in mice by feeding them a 60% high-fat diet (HFD) for 12 weeks before challenging them with a 4:3 cyclic IF regimen (consisting of 3 fasting days and 4 feeding days per week, 24 h each) for 18 days (Supplementary Fig