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Clinical Highlights of Retatrutide Study: 48-week, double-blind, placebo-controlled Phase 2 trial Results: ~22.8% weight loss (8 mg dose), ~28.2% weight loss (12 mg dose) ~0.9% HbA1c reduction Significant improvements in cardiometabolic risk factors Safety & Tolerability Most common side effects: nausea, vomiting, diarrhea, abdominal discomfort, constipation typically mild to moderate and dose-dependent

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The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity

While a promising approach, future work to address product stability and efficacy in larger eyes is needed for further development

Most treatments involve minimal discomfort