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Bonarrigo says

The ALDH2*1 allele encodes active acetaldehyde metabolising enzyme with G at nucleotide position 42 421 (its corresponding glutamate at amino acid position 487), whereas the ALDH2*2 allele encodes inactive enzyme with A at position 42 421 (its corresponding lysine at position 487)

doi: 10.1021/acsinfecdis.2c00193 [DOI] [PMC free article] [PubMed] [Google Scholar] [82].Bollen C, Dewachter L, Michiels J

GLOW patients from Closter schedule B12 injections during a short midday break

For example, certain antimalarial drugs, chemotherapy agents, or heavy metals may lead to oral pigmentation

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