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A systematic review discovered a dose-response relationship between cigarette consumption and the risk of miscarriage, with a 1% uptick in relative risk for each cigarette smoked per day, as described by Pineles et al

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The small sample size (n=58) may have limited the statistical power of the multivariable analyses, resulting in wider confidence intervals and reduced precision of the estimated effects

The public outcry from smokers and non-smokers, enforcement expenditures, illegal imports, anti-government action, and underground sales conspire to make absolute prohibition impossible