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Adolescents diagnosed with MDD exhibit a comparable profile characterized by heightened proinflammatory TNF- signaling and IL-6 trans-signaling, which correlates with an increase in IL-10- and IL-4-mediated anti-inflammatory activity [141]

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Plant-dominant low-protein diets (PLADO) can delay DKD progression through multiple mechanisms, including reducing dietary acid load, increasing dietary fiber intake, enhancing gut microbiota diversity, and reducing uremic toxin production (108)