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The key mechanisms involve: (1) enhancement of antioxidant defense systems via the activation of NRF2, GPX4, and SLC7A11

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BCKA treatment increased production of pro-inflammatory cytokines (MCP-1, TNF-) ( BCAA metabolic dysfunction-induced mitochondrial dysfunction and ROS production are also important mechanisms for inflammation exacerbation

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Critically, "Many patients regain two-thirds of their weight when coming off of these medications." These represent "not a quick fix for weight loss" but require "a commitment to regular injections and ongoing monitoring." 4