2021;321(5):E636E651
Obesity is a medical condition
Its mechanism mimics the action of a natural hormone that affects appetite regulation, leading to significant weight loss in clinical trials
97 Several regulators of microglial phagocytosis have been identified, including but not limited to tyrosine kinase-binding protein (TYROBP), 98 triggering receptor expressed on myeloid cells 2-apolipoprotein E (TREM2-APOE) pathway, 99,100 spleen tyrosine kinase (SYK), 101,102 classical complement system, 103 purinergic system, 104 sialic acid binding immunoglobin-like lectins (Siglecs) (CD22 and CD33), 105,106,107 TAM system, 77 and mechanosensor Piezo1
Duration of Treatment : Weight management with Semaglutide GLP-1 is often a long-term commitment
From there, youll titrate up based on your response and tolerance