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Promisingly, a systematic review of pharmacological models to investigate COPD drugs experimentally summarised that of all the models available (animal in vivo and in vitro, human in vitro and ex vivo), human ex vivo models were best to investigate antimuscarinic drugs for COPD

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It delivers nicotine, it changes the burn characteristics, it adds its own flavor to the smoke, and it introduces the respiratory concerns associated with tobacco combustion

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