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Scientists have identified hundreds of these naturally occurring peptides, and many have been replicated or synthesized for therapeutic use

Take first thing in the morning or 30 to 60 minutes before exercise

HbA1c reductions that rival insulin Across the SURPASS trial program, tirzepatide reduced HbA1c by up to 2.24%, bringing many participants to levels below the diabetic threshold

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However, this same mechanism also underlies many of the gastrointestinal side effects reported by patients