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Another study comparing association between tobacco smoking and chewing with risk of PID in two populations with different exposures showed that SLT users were at a five times higher risk of SIL in comparison to non-chewers irrespective of age (Simen-Kapeu et al

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Increased levels of ROS contribute to inactivation of antiproteases (such as a1-antitrypsin) and activation of metalloproteases (MMPs), resulting in protease/antiprotease imbalance in the lungs, which directly contributes to the degradation of the lung matrix [94]

While Conway was having lunch in the little restaurant below the hotel, "I looked up, and coming through the door was Lew Ayres, whom I hadn't seen in years and years

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Even so, the mechanistic picture points to risk, not benefit, especially with regular exposure