In some embodiments, the percentage of active agent is varied between about 1% and about 95%, between about 5% and about 80%, between about 10% and about 60% or more of the weight or volume of the total pharmaceutical formulation
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Compared to humans and mice, rats have a higher basal level of antioxidant defense gene expression, and rats have a greater capacity to respond to cellular stress, which makes them generally more resistant to drug toxicity [127]
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