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In mouse, a NOD.H-2h4 strain prone to AIT and susceptible individuals, excess I increases the number of intrathyroidal infiltrating Th17 and inhibits the development of Treg, causes abnormal expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in thyrocytes, leading to their apoptosis (44, 45)

The cortex and the medulla of kidney tissue can contain distinct types of tertiary lymphoid organs, which may possess pathogenic or regulatory properties

In the acute, early phase of pancreatitis, histamine levels throughout the body rise due to the production of histamine from pancreatic mast cells

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The data is promising but far from conclusive, and more research is needed to determine its true preventative potential

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