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The reduced calcium signaling impairs the activation of calcium/calmodulin-dependent protein kinase II (CaMKII), a key enzyme involved in the phosphorylation of various substrates that promote synaptic strengthening

The mechanisms by which LA reduces liver fat content in HFD animals may be related to suppressing oxidative stress and lipid peroxidation, improving mitochondrial dysfunction, inhibiting insulin resistance, and regulating some related factors or genes (such as ROS-scavenging enzyme genes) to inhibit excessive fat synthesis in the liver

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Cell Host Microbe 23 (6), 716724

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