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This is typically the most distressing phase

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Safety and medical context If you are on blood-glucose-lowering drugs or prescription weight-loss medications, coordinate any dietary changes or supplements with your prescribing clinician so medication doses can be adjusted safely

If a patient on semaglutide 2.4 mg (Wegovy) has not met that threshold after 16 weeks, switching to tirzepatide is a reasonable next step supported by that guideline framework

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Biochimica et Biophysica Acta (BBA) General Subjects, 1830(5), 31433153