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Mazini L, Rochette L, Admou B, Amal S, Malka G
Discontinuation rates due to AEs were 12.2% and 18.2% with Retatrutide 9 mg and 12 mg, respectively, compared to 4% with placebo
The findings are presented here for completeness of the published evidence base
Tirzepatide (Mounjaro/Zepbound) Discontinuation Patterns The SURMOUNT trials havent published official discontinuation data yet because patients are still being tracked
Stratified by GLP-1 related and non GLP-1 related treatments In the included RCTs, GLP-1 related drugs (including liraglutide, semaglutide, beinaglutide, exenatide, and AMG133) showed significant weight regain compared with control group (WMD = 1.78 kg, 95% CI 0.76 to 2.80, P = 0.006, I 2 = 85%)
But several other companies are working on semaglutide-like drugs, some will be cheaper to produce than semaglutide, and Morgan Stanley expects that this stronger level of competition will eventually drive costs down to $350/month ($4,000/year) by 2030
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