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The use of GLP-1 receptor agonists is frequently associated with gastrointestinal adverse effects, particularly nausea, vomiting, diarrhea or constipation
These symptoms are usually mild to moderate and tend to improve over time as your body adjusts to the medication
However, about 11% of those with T2DM did not respond even to the highest dose of tirzepatide [53-55]
However, many of the studies that have explored this question have been fairly small, short in duration, and focused on the most severe cases
In contrast, both semaglutide and tirzepatide treated groups showed a significant reduction in liver fibrosis compared to their respective diet-restricted controls
Going long periods without eating may lead to worse side effects like nausea
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