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For most people, gastrointestinal side effects are at their worst in the first two to four weeks of each new dose level and improve significantly as the body adjusts

This dual mechanism affects both its efficacy and its timing requirements

Oral NSAIDs such as ibuprofen or naproxen may be appropriate for moderate pain when used at the lowest effective dose for the shortest duration necessary, particularly in patients without cardiovascular disease, kidney disease, or gastrointestinal risk factors

doi:10.2147/MDER.S218983

Avoid touching the needle

According to brand materials, users may begin noticing changes within the first one to two weeks, with additional changes building gradually with continued use