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An alternate possibility is that cytosolic NADPH manipulation ultimately affects matrix NADPH status through metabolite shuttles, which are used to convey reducing equivalents across the mitochondrial membranes by coupling mitochondrial redox reactions with their cytosolic counterparts (for example, using the transport of citrate to couple IDH2 and IDH1) (Taylor, 2017)

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In bovine mammary-gland research, DES stimulated local cell proliferation at doses 10-fold lower than native IGF-1, demonstrating potency that is site-specific rather than systemic [11]

A much smaller share of workers is covered by their employers health benefits at firms with many low-wage workers (43%) than at firms with few low-wage workers (64%)

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