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Scatchard plot analyses indicate specific, saturable binding with Kd values typically ranging from 0.1-1.0 nM in various cell line models

Low SLC46A3 expression is correlated with the T-DM1 resistance phenotype and can serve as a predictive biomarker for its efficacy [119]

It has not received marketing authorisation from the MHRA or EMA and is not available as a licensed medicine in the UK

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Sterile Sodium Chloride 0.9 percent, Hospira sterile water for injection, and preservative-free, sterile and chemical-free solutions

However, E2 continues to be produced postmenopausally in extragonadal sites from the aromatization of androgens, where it acts locally in an autocrine or paracrine manner (15, 16)