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PloS One, 9 (8), e104263

AC system activation generates an increase of the intracellular secondary messenger, cyclic adenosine monophosphate (cAMP), through the conversion of adenosine triphosphate, which then results in the activation of protein kinase A (PKA) and exchange protein activated by cAMP (Epac) [32,33,34,35]

Kawamoto, Y., Wu, Y., Takahashi, Y

1996 Jan 16;61(1)1-18

Studies on animal models have shown that Ipamorelin stimulates the secretion of growth hormone (GH) from somatotropic pituitary cells in a selective manner without the accompanying significant increase in cortisol, aldosterone or prolactin concentrations, which is observed with the administration of other GHRPs, such as GHRP-6 or GHRP-2

Diabetes Care 2009;32:493-8.PubMedPMC 675