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These were treatment-seeking participants
Given these concerns, the JDS has issued the "Recommendations for Safe Use of Incretin-Based Therapies, Second Edition" (Table 1) [13] emphasizing that careful consideration of hypoglycemia risk, remaining -cell function and mass, gastrointestinal side effects is essential when determining tirzepatide indications and treatment continuation
Satiety arrives sooner and lasts longer between meals
Clinical trials showed average weight loss of 20-22% of body weight over 68 weeks, but individual results range from 15% to 30% depending on genetics, starting weight, and adherence
