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Role of Mitochondrial Pyruvate Transport in Disease In animal studies, where the transport of pyruvate into the mitochondria via the MPC has been disrupted by gene deletion or by pharmacological inhibition, a beneficial effect is observed at the level of insulin resistance, blood glucose homeostasis, diabetes, and the development of metabolic dysfunction-associated steatohepatitis, MASH (commonly referred to as non-alcoholic steatohepatitis: NASH)
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In brief, NRF2 detaches from Kelch-like ECH-associated protein 1 and translocates to the nucleus, where it activates the expression of downstream target genes containing antioxidant responsive elements
Oligodendrocytes, may not have a direct metabolic role but are key to CNS myelination, and thus expend a large amount of ATP during development (Kuhn et al., 2019)