The data sources used in this analysis were from UK Clinical Practice Research Datalink (CPRD) GOLD database 75 and merged with Hospital Episode Statistics linkage information and death registry data from the Office for National Statistics
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In some cases, this slowing down of the process causes both diarrhea and constipation
Importantly, gastrointestinal adverse events (nausea, vomiting, diarrhoea) occurred in 3045% of participants during dose escalation but typically resolved within 48 weeks