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At therapeutically and research-relevant doses, MC4R is the primary pharmacologically active receptor both because it has the highest CNS expression density in regions governing sexual behaviour and because MC1R-mediated pigmentation effects (the basis of the tanning response to MT-II) are substantially attenuated in PT-141s cyclic structure

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Proteome analysis of PC12 cells reveals alterations in translation regulation and actin signaling induced by clozapine

Estradiol modulates thermogenesis at three points on this VMH-SNS-BAT pathway: 1) through its effects on the VMH nucleus 2) through its effects on SNS signaling 3) directly through its effects on BAT

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