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But this synergy depends entirely on receptor availability and circadian priming

doi: 10.1182/blood-2005-06-2202 85 YeamanMR

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When Histamine Symptoms Extend Beyond Food A low-histamine diet may reduce meal-triggered symptoms, but it cannot by itself determine whether the patient has undermethylation, copper overload, pyroluria, mast-cell activation or another biochemical pattern