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Increased toxicity of a pharmacologically active metabolite of irinotecan (SN38) has been described in patients suffering from Gilberts syndrome as UGT1A1 is the main enzyme responsible for the formation of the inactive SN38 glucuronide (Wasserman et al., 1997)

F., Buisson-Ferey, J., Sachs, M., Hirsch, J

Once again, there is not enough evidence through clinical trials for these treatments to be used consistently with confidence, and they usually just act as complimentary treatments

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