4.2 Targeting Gln metabolism to inhibit tumor proliferation 4.2.1 Inhibition of Gln uptake Tumor survival and proliferation are heavily dependent on Gln, a hydrophilic amino acid that must be transported into tumor cells by transmembrane proteins, such as SLC1A5, SLC6A14, and SLC38A1/2
GST, glutathione transferase
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This highlights PPARa as a potential therapeutic target for TSCI and related neurodegenerative conditions
Other downregulated transcripts included membralin isoform X1, leucine-rich repeat neuronal protein 1, and abnormal spindle-like microcephaly-associated protein isoform X1