Lipoic acid but not dihydrolipoic acid can react with specific sulfhydryl residues of Keap1, causing the release of Nrf2 (34)
Elective surgery has also long been used as a paradigm of the stress response in humans (188-190): the magnitude of cortisol rise correlates positively with the severity of surgery (191)
Together, they address both targeted healing and body-wide regeneration support
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Decreased sympathetic nerve firing leads to arterial vasodilation, resulting in reduced total peripheral resistance (TPR), and venodilation, resulting in decreased venous return (preload)
In the orthopedic literature, reviewers describe preclinical work involving muscle, tendon, ligament, and bone injury models, with proposed effects on growth hormone receptor expression, angiogenesis-related pathways, and inflammatory cytokines (Emerging Use of BPC-157 in Orthopaedic Sports Medicine)