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Further investigation is necessary to determine whether the Trx system can accurately predict immunotherapy sensitivity and even combination therapies

Latest developments demonstrate that redox-sensitive nanoparticles, such as disulfide bond-containing nanoparticles, can respond to elevated concentrations of glutathione (GSH) in tumors

In the following sections, we summarize some of the most important aspects of mGSH physiology, its role in mitochondrial function and release of mitochondrial apoptotic factors and the impact of its depletion in disease

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