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The cumulative fractional labeling from palmitate and glucose in DKO cell histone acetylation matches that by WT and ACSS2 KO cells, while ACLY KO cells have much lower cumulative labeling from these two sources, consistent with unlabeled acetate feeding the acetyl-CoA pool only in those cells (Supplemental Figure 5D)

The link between lysosomal dysfunction and autophagy inhibition is robustly supported by the findings from lysosomal storage diseases (LSDs)

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PlexusDx compounded semaglutide is sourced from licensed 503A pharmacies and carries the same safety considerations as brand-name semaglutide

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