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Another study found that over about a year and a half, those taking semaglutide lost around 14% of their body weight on average, compared to only about 2% weight loss for those taking a placebo

Inadequate dosing intervals, missed injections, improper injection technique, concurrent medications that interfere with GLP-1 signaling, and unaddressed metabolic conditions (like thyroid dysfunction or polycystic ovary syndrome) can all suppress apparent medication response

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GLP-1 Medications Work Best on a Consistent Schedule GLP-1 medications work best when taken consistently, says Dr

What to look for: A prescriber who asks how youre tolerating the current dose before escalating, not one who escalates by default at every visit