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Improvements were seen in individual MACE components (secondary endpoints): superior reductions were seen in nonfatal stroke for sc semaglutide in SUSTAIN 6 (HR 0.61 [95% CI: 0.380.99]) and for dulaglutide in REWIND (HR 0.76 [95% CI: 0.610.95]), and in CV death for liraglutide in LEADER (HR 0.78 [95% CI: 0.660.93]) and for oral semaglutide in PIONEER 6 (HR 0.49 [95% CI: 0.270.92])

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Mitochondria, which are structures within the cells of the RPE that act as energy powerhouses, are particularly susceptible to ROS-induced damage [17]

However, it is yet to be approved for any indications beyond glycemic control

Semaglutide is commonly prescribed in doses ranging from 0.25 mg to 2.4 mg