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The mechanism accounting for this effect is unknown but a leading hypothesis is that an increase of sodium chloride in the macula densa due to SGLT2 inhibition triggers a cascade that reduces GFR through constriction of the afferent glomerular arterioles (tubuloglomerular feedback) (139,195)

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doi: 10.1186/s13099-024-00635-7 362 ZengZChenMLiuYZhouYLiuHWangSet al

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