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Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes

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Optimizing Gut Microbiota: GLP-1 receptor activation alters gut microbial composition (e.g., increasing short-chain fatty acid-producing bacteria) to inhibit energy absorption

In the case of the fat-derived hormone leptin, this is believed to be facilitated by tanycytes lining the floor of the third ventricle in a two-step process

Liraglutide (Saxenda) was the first GLP-1 RA approved for chronic weight management in adults with obesity or overweight and at least one weight-related comorbidity, and it was later approved for use in adolescents aged 12 years