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doi:10.1002/oby.70231 @MayoClinic The sex difference showing up in both the trial and the real world data is getting hard to ignore

Schattenberg JM, Wang Y, Singh R, Rigoli RM, Czaja MJ (2005) Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling

Insulin has been the recommended ADM during pregnancy, as it does not cross the placenta and is, therefore, unlikely to cause malformations

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In the Phase III ADVANCE trial, biweekly 125 g dosing reduced the annualized relapse rate by approximately 36% and new T2 lesion count by 67% versus placebo at one year (196)

2 weeks after the treatment, youre likely to see the results of your treatment