Similar to our primary analysis, we calculated 3 different comorbidity scores: the VHA frailty index 60 , the weighted CCI 61,62 ,and cardiovascular risk as calculated by DAgostino method 63
The lure of the obesity drug market was the impetus in a bidding war between Pfizer and Novo Nordisk for acquiring Metsera, a New York-based clinical-stage bio/pharmaceutical company focused on obesity and cardiometabolic diseases, with Pfizer emerging victorious with a successful offer, worth up to $10 billion, in a deal that closed last month (November 2025)
Citation [1] Park JR, Lee H, Kim SI, Yang SR
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Additionally, GLP-1 receptors are present in the brainstem area postrema, a region involved in the vomiting reflex, and direct stimulation of these receptors may contribute to nausea and emesis
More interestingly, male Sprague-Dawley rats were randomly divided into the normal control (NC) group, high-fat (HF) group, and HF+Lira (GLP-1RA) group
