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Biguanide-derived neuroprotective agent (metformin) To mitigate neuroinflammation and mitochondrial dysfunction in PD, metformin was encapsulated into PLGA, which were further coated with BV2 microglial cell membranes to enhance the targeting efficiency to neuroinflammatory sites (BV2-metformin-loaded PLGA) for intranasal administration 19
Insulin resistance is assessed using various methods, including HOMA-IR, hyperinsulinemiceuglycemic clamp (the gold standard), fasting insulin, or HbA1cmethods that differ significantly in sensitivity and physiological meaning
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Other drugs under investigation, and possibly in the pipeline for the next couple of years, include CagriSema, based on cagrilintide (which suppresses appetite by targeting the amylin receptor) and semaglutide
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Nitrogen adsorption-desorption isotherms at 77 K were measured using a Micromeritics TriStar sorptometer (Micromeritics Instrument Corporation, Norcross, GA, USA) to measure the specific surface area, pore size distribution, and pore volume of the samples
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