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You should discuss alternatives with your prescriber if: Severe reflux persists despite maximum medical therapy (twice-daily PPI plus lifestyle modifications) for more than 8 weeks

In AP, excessive ROS not only inhibits the normal function of autophagy but may also alter autophagy regulation by activating autophagy-related genes, such as glutamic oxaloacetic transaminase, leading to the accumulation of damaged materials within cells and exacerbating pancreatic injury (116)

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This gradual titration helps minimise gastrointestinal side effects, which are common with GLP-1 receptor agonists

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GPER-1 belongs to the family of G protein-coupled receptors, and, in humans, its gene is located in chromosome 7p22.3, which encodes a sequence of 375 amino acids with a relative molecular mass of 41 kDa