[1] [2] These typically diminish over time as the body adjusts to the medication
Other conditions worth considering include: Type 2 diabetes or non-diabetic hyperglycaemia (sometimes called pre-diabetes) , which involves insulin resistance affecting how the body stores fat Depression and anxiety , which can affect appetite regulation, sleep, and motivation Obstructive sleep apnoea (OSA) , which disrupts hormones that control hunger and satiety common features include loud snoring, witnessed pauses in breathing during sleep, and excessive daytime sleepiness None of these conditions should be assumed without proper clinical assessment, but they are important to rule out when weight loss proves persistently difficult
No further treatment-switching steps were modeled in the base case analysis
Consistency matters more than specific timing, so choose whatever schedule you can maintain reliably
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