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This meta-analysis of randomized controlled trials did not highlight any detrimental effect of these drugs on mental health, including suicide

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Accessed 6/5/2024, Storhaug CL, Fosse SK, Fadnes LT

Product carbon footprint can be reduced by examining the whole lifecycle and identifying ways to achieve climate neutrality and net zero emissions

Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency

Symptoms are typically dose-related and occur early in treatment, with many patients seeing improvement within a few weeks as the body adapts to slower gastric emptying and central effects