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It remains to be investigated how MSH deficiency contributes to these transcriptome changes and whether the differential gene expression contributes to virulence and fitness for M

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Inhibitors and substrates enter/leave the active center by a so-called side opening ( DPP4 substrates In theory, numerous peptides are potential DPP4 substrates since they contain the cleavable amino acid sequence at their penultimate position, but not for all of them it could be shown that DPP4 is able to cleave them in vivo