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Animal studies confirm that removing ovarian function in mice leads to increased adipose tissue mass, adipocyte hypertrophy, and metabolic complications, all reversed with estrogen supplementation

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Phase 2 trial data showed average weight loss of up to 24.2% at 48 weeks, while the newer Phase 3 trial data showed 28.7% average weight loss at 68 weeks on the 12mg dose

In hindsight, 44% of Gen Z regretted brushing off early side effects as unimportant when they started their treatment

Specifically, we dissect how baseline microbial signatures correlate with differential efficacy, while critically assessing clinical confounding factors, such as metformin co-treatment and dietary shifts, and the methodological limitations that currently hinder the translation of microbiome profiling into precision endocrinology

For many, diet and exercise arent enough