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The clinical outcomes from compounded GLP-1 medications mirror those seen in major trials

According to medical and regulatory reporting , there are no FDA-approved GLP-1 patches

The lack of formal ethics-committee review of the rechallenge, already noted, is a governance limitation in its own right

Time constraints are another major issue

If features of Cushing's syndrome are present (such as central weight gain, easy bruising, or stretch marks), an endocrine referral may be appropriate

Oral melanoacanthoma was first reported in 1978 [2] and to the best of our knowledge, only 50 cases of melanoacanthoma have been reported in the literature to date (Table 1) [214]