2015 DOI: 10.1001/jamadermatol.2014.1875 PMID: 25230094 Read on PubMed British Journal of Dermatology Long-term observational study of afamelanotide in 115 patients with erythropoietic protoporphyria Biolcati G, Marchesini E, Sorge F, Barbieri L, Schneider-Yin X, Minder EI 2015 DOI: 10.1111/bjd.13598 PMID: 25494545 Read on PubMed Drugs Afamelanotide: A Review in Erythropoietic Protoporphyria Lane AM, McKay JT, Bonkovsky HL 2016 DOI: 10.1007/s40265-016-0579-y PMID: 26979527 Read on PubMed Journal of Investigative Dermatology Effect of MELANOTAN, [Nle4, D-Phe7]--MSH, on melanin synthesis in humans with MC1R variant alleles Dorr RT, Ertl G, Levine N, Brooks C, Bangert JL, Powell MB, Humphrey S, Alberts DS 2006 DOI: 10.1111/j.1600-0749.2005.00284.x PMID: 16293341 Read on PubMed JAMA Dermatology Association of Afamelanotide With Improved Outcomes in Patients With Erythropoietic Protoporphyria in Clinical Practice Wensink D, Wagenmakers MAEM, Barman-Aksoezen J, Friesema ECH, Cnossen MH, Hanssen-Rebel LMJ, Koole-Lesuis R, van Roij M, Langendonk JG 2020 DOI: 10.1001/jamadermatol.2020.0352 PMID: 32186677 Read on PubMed International Journal of Dermatology Risks of unregulated use of alpha-melanocyte-stimulating hormone analogues: a review Habbema L, Halk AB, Neumann M, Bergman W 2017 DOI: 10.1111/ijd.13585 PMID: 28266027 Read on PubMed 9 peer-reviewed references listed
Goals differantioxidant status, skin tone, recovery, or immune support may follow different timelines
The typical online intake process takes 1020 minutes: Complete an online medical history questionnaire (BMI, comorbidities, medications, contraindications) Provide ID verification and any required documentation Video or asynchronous consultation with a licensed clinician Prescription issued and routed to the program's compounding or retail pharmacy Medication ships directly to your address (typically 27 days) For physician-led programs like our #1 pick NexLife, ongoing care includes scheduled follow-ups at weeks 4, 12, 26, and 52, with adjustments to dose, coaching, and labs as needed throughout the year
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