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Mild side effects like temporary discomfort at the IV site, headache, or nausea can occur

The affinity chromatography purification reagent has low Ni 2+ leakage, high protein-binding capacity and stability, and is compatible with a wide range of chemicals and pH values, making it ideal for high performance purification of polyhistidine-tagged proteins expressed in E.coli , yeast, insect and mammalian expression systems

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Even well-maintained systems can be caught off guard by this sudden contamination event

doi: 10.1093/humupd/dmw023